Fentanyl Citrate Injection

Indications for Fentanyl Citrate Injection 3 vials per package

It is a short-term analgesia used during anesthetic periods, induction, premedication, and maintenance, and during immediate postoperative times as need arises. It is an analgesic supplement in regional or general anesthesia. It is concomitant with neuroleptic-like droperidol as an anesthesia induction and as an adjunct in maintaining local and general anesthesia. Used as an anesthetic together with oxygen in selected high-risk patients like those undergoing open-heart surgery, orthopedic procedures or complicated neurological.

Adult

Doctors administer the dose differently to each.

For premedication

, 50-100mcg 0r 1-2ml by IM injection is given 30-60 minutes before surgery or other medical procedures.

For adjunct to regional anesthesia

, 50-100mcg or 1-2mL via slow IV or IM injection for 1-2 minutes.

Post operation

: 50-100mcg or 1-2ml via IM injection. This can be repeated in 1-2 hours as required.

General anesthetic

: 50-100mcg per kg or 1-2ml per kg. The doctor can administer it with oxygen and a muscle relaxant. In cases like complicated neurological, open-heart surgery, or orthopedic procedures, doses of up to 150mcg/kg or 3ml per kg can be required. It is wise to reduce the dose in the cases of debilitated or the elderly.

Note that children below two years should not take this drug. The induction and maintenance dose for those who are 2-12 years is 2-3mcg per kg.

Warnings and precautions

Only people who are skilled explicitly in IV anesthetics and respiratory management in a recognized facility should administer this drug. When giving this medicine, there should be an opioid antagonist, intubation and resuscitate equipment, and oxygen readily available. The doctor should monitor respiratory depression strictly especially after an operation. Patients with a history of head injury or brain tumor, hypertension, increased intracranial pressure, pulmonary disease, drug abuse, cardiac bradyarrhythmias should avoid a drug. Doctors should monitor vital signs routinely. The medication is not recommended for debilitated, elderly pregnant women, and nursing mothers.

Interactions

People who are within two weeks of MAOIs should be cautious with this drug. The drug can also interact with high doses of fentanyl and nitrous oxide to cause cardiovascular depression. When it interacts with concomitant droperidol, it can cause a decrease in pulmonary arterial hypotension and pressure.  It causes additive effects when it interacts with other CNS depressants like tranquilizers, barbiturates, narcotics, or general anesthetics. It is wise to reduce dosage if you are taking these drugs too.

Fentanyl Citrate Injection adverse side effect

• Apnea
• Hypotension
• Respiratory depression
• Bradycardia
• Emesis
• Skeletal muscle rigidity
• Hypertension
• Dizziness
• Blurred vision
• Diaphoresis
• Nausea
• Laryngospasm